Targeting HIF-1α rescues microglial efferocytosis via the SLC7A11-TAM pathway to ameliorate Sepsis-associated encephalopathy - PubMed
4 hours ago
- #Microglial Efferocytosis
- #Sepsis-associated encephalopathy
- #HIF-1α
- Microglial efferocytosis impairment is a key feature in sepsis-associated encephalopathy (SAE).
- HIF-1α upregulation interacts with SLC7A11 to suppress the TAM-Rac1-NCKAP1 axis, leading to efferocytic failure.
- Targeting HIF-1α with KC7F2 rescues efferocytosis, reduces inflammation, and improves cognition and survival in SAE models.
- The study identifies the HIF-1α-SLC7A11 pathway as a driver of microglial dysfunction in SAE and suggests HIF-1α as a therapeutic target.