Characterization of the plasma proteomic profile of dual trajectories in cognitive status and physical performance - PubMed
4 hours ago
- #Cognitive Decline
- #Proteomics
- #Aging
- The study investigated plasma proteomic signatures linked to dual declines in cognitive status and physical performance in older adults from the Invecchiare in Chianti cohort.
- Three trajectory groups were identified: no decline, physical decline only, and dual decline (both cognitive and physical).
- Eight proteins were associated with differences across groups: higher levels of PI3, GDF15, TFF3, CCL15, TNNT2, and AGRP increased odds of dual decline, while higher CKM and GHR decreased odds.
- PLS-DA highlighted PTN, TFF3, GDF15, IGFBP-2, and CHRDL1 as top discriminators, with PTN, IGFBP-2, PI3, GDF15, and TFF3 forming a coherent module.
- Functional enrichment indicated overrepresentation of IGF transport regulation and exploratory links to post-translational phosphorylation and homeostasis diseases.
- The dual decline proteomic profile suggests mechanisms involving cellular stress, inflammation, barrier injury, reduced IGF-1 bioavailability, and cardiovascular-metabolic strain.