Intermittent Fasting Attenuates Cognitive Decline in D-Galactose-Induced Aging Rats in Association with β-Hydroxybutyrate and PI3K/AKT/GSK-3β Signaling - PubMed
3 hours ago
- #Cognitive Decline
- #Intermittent Fasting
- #Neuroprotection
- Intermittent fasting (IF) improved cognitive functions in aging rats, including recognition memory and spatial learning/memory, as shown by behavioral tests.
- IF increased serum levels of β-hydroxybutyrate (BHB), reduced neuroinflammation and tau phosphorylation, and restored brain-derived neurotrophic factor (BDNF) expression.
- The cognitive benefits of IF were associated with modulation of the PI3K/AKT/GSK-3β signaling pathway, as inhibition of PI3K attenuated these improvements.
- Transcriptomic analysis indicated that IF suppressed senescence-related genes and modulated neuroprotective pathways in the brain.
- The study suggests IF as a potential non-pharmacological intervention for age-related cognitive decline, though further validation on ketone metabolism is needed.