Endogenous aldehydes: A driver of clonal hematopoiesis from within? - PubMed
5 hours ago
- #Clonal Hematopoiesis
- #Endogenous Aldehydes
- #Hematopoietic Stem Cells
- Detoxification of endogenous aldehydes is critical for preserving genomic integrity in hematopoietic stem cells.
- Excess formaldehyde can drive clonal hematopoiesis by reducing blood-forming progenitor cells.
- This aldehyde-driven clonal hematopoiesis occurs through neutral drift, without known genetic drivers of positive selection.