Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation - PubMed
4 days ago
- #neutrophils
- #psoriasis
- #tumorigenesis
- Psoriasis-like disease prevents squamous skin tumor development through neutrophil-driven inflammation.
- Neutrophil-dependent inflammation in psoriasis-like skin leads to infiltration of CD54-expressing neutrophils, release of cytotoxic granules, and neutrophil extracellular traps (NETs).
- Keratinocytes in psoriasis-like skin show enhanced senescence and diminished responsiveness to mitogenic signals like epidermal growth factor and Wnt/β-catenin.
- Neutrophil depletion reduces psoriasis-like inflammation, abolishes keratinocyte senescence, and restores tumor growth.
- The study suggests that neutrophil granules and NETs eliminate tumor cells or induce senescence in keratinocytes, preventing tumor growth.
- Findings highlight an innate control mechanism of skin tumorigenesis in psoriasis-like disease, relevant for cancer prevention strategies.