Oxidative stress and bone marrow adipocytes: Molecular mechanisms and possible implications - PubMed
6 hours ago
- #Bone marrow adipocytes
- #Osteoporosis
- #Oxidative stress
- Redox homeostasis is crucial for skeletal health and linked to osteoblast and osteoclast differentiation.
- Oxidative stress influences bone marrow adipocytes (BMAs) differentiation, leading to bone marrow adipose tissue (BMAT) accumulation and bone remodeling imbalances.
- BMAs expansion affects bone marrow-derived mesenchymal stem cells (BMSCs), resulting in poor osteoblast differentiation and enhanced osteoclast activity.
- Oxidative stress and BMAs differentiation are interconnected, with BMAs amplifying oxidative stress levels in the bone microenvironment.
- Maladaptive BMAs differentiation disrupts osteoblast-osteoclast equilibrium through paracrine signaling and microenvironmental changes.
- Targeting BMAs offers a novel therapeutic approach for osteoporosis, addressing bone quality and fracture healing beyond just bone mineral density.