A nature-derived, strong adhesive hydrogel microsphere for wet tissue repair: Multifunctional and clinical potential - PubMed
6 hours ago
- #tissue-repair
- #hydrogel
- #biomimetic
- A nature-derived, strong adhesive hydrogel microsphere (SGM) was developed for wet tissue repair, inspired by the adhesive mechanisms of Andrias davidianus skin section (SSAD).
- SGM combines strong bioadhesion, cell/drug delivery capabilities, and extracellular matrix (ECM) remodeling, making it a multifunctional biomimetic platform.
- Preclinical evaluations showed SGM's exceptional adhesive strength under continuous fluid shear stress, outperforming conventional hydrogel microspheres.
- SGM significantly enhanced tissue repair in various wet tissue models, including bone, cartilage, and soft tissues, by delivering therapeutic agents and promoting ECM remodeling.
- The study introduces a promising class of wet-adhesive microspheres with broad potential for fluid-rich tissue regeneration scenarios.