Parvimonas micra-derived SirTM: An ADP-ribosyltransferase as a novel driver in colorectal cancer progression - PubMed
5 hours ago
- #colorectal-cancer
- #Parvimonas-micra
- #ADP-ribosyltransferase
- Parvimonas micra (P. micra) is implicated in colorectal cancer (CRC) development, but its virulence factors and mechanisms are not well understood.
- 99 strains of P. micra were isolated from CRC tissues, revealing strain-level variations in CRC promotion.
- SirTM, a virulence factor in P. micra with ADP-ribosyltransferase activity, was identified as a driver of CRC progression.
- SirTM targets histone H2B, modifying it with ADP-ribosylation, and promotes CRC via the CEBPβ/SAA1/IL-17C signaling pathway.
- SirTM is a potential biomarker target, and SAA1 is a potential therapeutic target in CRC.
- P. micra releases SirTM into CRC cells, facilitating CRC development through the CEBPβ/SAA1/IL-17C pathway.