Thyroid-stimulating hormone receptor mediates peripheral-central neuroimmune crosstalk in autoimmune thyroid diseases - PubMed
2 hours ago
- #TSHR
- #neuroimmunology
- #autoimmune thyroid disease
- TSHR mediates neuroimmune communication between peripheral and central systems in autoimmune thyroid diseases like Graves' disease and Graves' orbitopathy.
- Multi-omics and imaging analyses identified TSHR as a shared genetic driver expressed in brain cells and immune cells, with validated interactions in the basal ganglia.
- Structural modeling and screening suggested three repurposable compounds (venetoclax, irinotecan, dutasteride) as potential TSHR modulators for therapy.
- The study supports a 'disease-molecule axis' framework linking genetics to immune and neural mechanisms, though limitations like sample size require further validation.