Revitalizing p-GSK-3β via cysteine sulfenylation promotes hepatic insulin resistance by differentially regulating glycogenesis and gluconeogenesis - PubMed
4 hours ago
- #gluconeogenesis regulation
- #hepatic insulin resistance
- #GSK-3β sulfenylation
- Insulin signaling-inactivated p-GSK-3β is reactivated through reactive oxygen species-mediated sulfenylation, contributing to hepatic insulin resistance.
- Sulfenylated p-GSK-3β phosphorylates liver glycogen synthase to halt glycogenesis and phosphorylates Forkhead box O1 to promote gluconeogenesis.
- This dual-pathway mechanism is observed in human liver samples and organoids, offering a potential therapeutic target for hepatic insulin resistance.