Shared immune dysregulation in systemic lupus erythematosus and colorectal cancer: a multi-omics guided discovery of DNASE1L3-centric efferocytosis deficiency - PubMed
7 hours ago
- #multi-omics
- #efferocytosis
- #immune dysregulation
- Shared immune dysregulation between systemic lupus erythematosus (SLE) and colorectal cancer (CRC) was investigated.
- Multi-omics analysis identified 58 shared differentially expressed genes (DEGs) enriched in apoptosis, oxidative phosphorylation, and immune infiltration.
- Four hub genes (DNASE1L3, PTPN14, SELENBP1, ECRG4) were highlighted by machine learning, forming a predictive model for SLE and CRC.
- DNASE1L3 knockdown in THP-1 cells impaired macrophage efferocytosis, altered macrophage polarization, and affected cytokine levels.
- Shared immune profiles and signaling pathways suggest potential for precise intervention strategies in both diseases.