NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes - PubMed
4 hours ago
- #NUDT1
- #Prognosis
- #Osteosarcoma
- NUDT1 is significantly upregulated in osteosarcoma (OS) tissues and cell lines.
- High NUDT1 expression is an independent predictor of poor overall survival in OS patients.
- NUDT1 promotes OS cell proliferation, migration, invasion, and tumor growth in experimental models.
- Mechanistically, NUDT1 is linked to metabolic pathways like glycolysis and glutathione metabolism, and it reduces ROS accumulation and oxidative DNA damage.
- NUDT1 expression correlates with the immune microenvironment, particularly with CD8+ T cell and Naïve B cell infiltration.
- NUDT1 levels may predict sensitivity to topoisomerase inhibitors such as Topotecan and Irinotecan.
- NUDT1 is proposed as a prognostic biomarker and therapeutic target in OS.