A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation - PubMed
4 hours ago
- #Fusion Protein
- #Tuft Cells
- #Intestinal Regeneration
- A synthetic Wnt-IL-13 fusion protein activates both Wnt and IL-13 signaling pathways to enhance tuft cell activity.
- This therapeutic approach promotes mucosal healing and intestinal regeneration using human organoid models.
- It addresses conditions like inflammatory bowel disease and graft-versus-host disease by overcoming limited regenerative responses.
- Human intestinal tuft cells are key to tissue repair, and activating them drives effective regeneration.