Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study - PubMed
5 hours ago
- #Cardiometabolic Diseases
- #Proteomics
- #PRISm
- A 29-protein signature is identified in plasma proteomic profiling that links preserved ratio impaired spirometry (PRISm) to cardiometabolic diseases.
- Protein signatures improve prediction of cardiometabolic outcomes such as type 2 diabetes, ischaemic heart disease, stroke, and multimorbidity over covariates alone.
- Mediation analyses show proteins like IGSF3 and GDF15 significantly mediate associations between PRISm and cardiometabolic diseases, involving inflammatory and metabolic pathways.