Endothelial FOXO1 Lactylation: A New Link Between Disturbed Flow and Atherosclerosis - PubMed
6 hours ago
- #atherosclerosis
- #lactylation
- #endothelial cells
- The editorial discusses a novel mechanism linking disturbed blood flow and atherosclerosis via endothelial FOXO1 lactylation.
- Disturbed flow conditions are shown to reprogram endothelial cells into immune-like and foam cell phenotypes, particularly under hypercholesterolemia.
- FOXO1 lactylation, a post-translational modification, is identified as a key mediator in this process, connecting mechanical forces to cellular metabolic and inflammatory responses.
- The findings highlight the role of oxidative phosphorylation and protein processing in endothelial dysfunction during atherogenesis.