Integrative Molecular Insights Into Epidemiological, Genetic, and Metabolic Risk Factors of Gallbladder Cancer: Implications for Biomarkers, Therapeutic Targeting, and Future Perspectives - PubMed
3 days ago
- #biomarkers
- #gallbladder-cancer
- #metabolic-reprogramming
- Gallbladder cancer (GBC) is a rare but highly aggressive malignancy with a five-year survival rate of less than 5%.
- Risk factors for GBC include geographic variation, genetic predisposition, environmental exposures, chronic inflammation, and infections.
- Metabolic reprogramming is a central driver of GBC carcinogenesis, involving altered lipid metabolism, bile acid signaling, and redox imbalance.
- Key molecular pathways in GBC include NF-κB activation, oxidative stress, PI3K/AKT-mediated metabolic remodeling, and DNA damage repair defects.
- The review highlights opportunities for biomarker discovery, metabolic imaging, early detection, and targeted therapeutic development in GBC.