Longitudinal association between sleep and Alzheimer's pathology - PubMed
3 days ago
- #Alzheimer's disease
- #PET imaging
- #sleep disturbance
- Sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD).
- Study included 223 cognitively unimpaired participants with sleep measures and PET scans for AD pathology.
- Actigraphy-based sleep variability measures were associated with tau burden.
- Greater variability in sleep fragmentation was linked to amyloid burden.
- Irregular sleep patterns are associated with higher pathological burden and faster amyloid accumulation.