A comprehensive single-cell analysis reveals the impact of laser interstitial thermal therapy on the tumor microenvironment in glioblastoma - PubMed
6 hours ago
- #glioblastoma
- #tumor microenvironment
- #laser interstitial thermal therapy
- Glioblastoma (GBM) is a lethal intracranial malignancy with limited treatment options.
- Laser interstitial thermal therapy (LITT) is a minimally invasive treatment for GBM.
- Sublethal hyperthermia (below 46°C) in the peripheral tumor region affects invasive GBM cells.
- Sublethal hyperthermia promotes cytotoxic T cell infiltration and dendritic cell maturation.
- It enhances germinal center B cell recruitment and reduces M2 macrophage infiltration.
- Sublethal hyperthermia decreases GBM malignancy and DNA repair capacity.
- Key changes include enhanced interactions between extracellular matrix-related cells and GBM.
- Sublethal hyperthermia suppresses tumor by weakening collagen-related gene and Cd44 interactions.
- It promotes tumor angiogenesis and proliferation via Ptn and Ncl interaction.
- The study provides insights into LITT's complex effects on GBM and potential therapeutic targets.