Characterization, immune cell phenotyping and differential gene expression analysis of brain metastases and primary breast cancer samples - PubMed
5 hours ago
- #immune profiling
- #brain metastasis
- #breast cancer
- Integrated analysis of paired brain metastases and primary breast tumors reveals receptor status changes, including estrogen receptor and HER2 expression alterations.
- RNA sequencing shows downregulation of immune-related genes in brain metastases, indicating a less immunogenic environment.
- Immune profiling indicates reduced B- and CD8+ T-cell infiltration in brain metastases, with an increase in immunosuppressive M2 macrophages and follicular helper T-cells.
- Findings suggest a more immunosuppressive tumor microenvironment in brain metastases, potentially contributing to immune evasion and reduced response to checkpoint inhibitor therapy.
- Study highlights molecular and immunological differences, but limitations include small sample size and descriptive nature of results, calling for investigation in larger cohorts.