The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation - PubMed
5 hours ago
- #Plasma amino acids
- #Abdominal aortic aneurysm
- #Mendelian randomization
- Abdominal aortic aneurysm (AAA) is a severe vascular condition with high mortality upon rupture.
- Study investigates causal relationship between plasma amino acids and AAA using Mendelian randomization (MR) and in vivo validation.
- Five amino acids causally linked to AAA risk: aspartate, glutamate, glycine (increased risk), proline, tryptophan (reduced risk).
- Proline supplementation showed therapeutic potential in inhibiting AAA development in mouse models.
- Findings suggest proline could be a potential therapeutic strategy for AAA.