Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery Disease - PubMed
2 days ago
- #Limb Ischemia
- #Peripheral Artery Disease
- #Intramuscular Adipose Tissue
- Intramuscular adipose tissue (IMAT) accumulation is linked to impaired limb function in peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI).
- Patients with CLTI show higher adipogenic gene and protein expression in muscle compared to non-PAD controls.
- Murine models indicate that increased IMAT worsens ischemic limb muscle strength, while preventing IMAT improves it.
- Female mice tend to form more IMAT than males, but the functional impact is consistent across sexes.
- Targeting IMAT formation could be a novel therapeutic strategy to improve limb function in PAD/CLTI patients.