Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia - PubMed
4 hours ago
- #Ageing Biomarkers
- #Metabolomics
- #Dementia Risk
- Metabolomic ageing (MileAge) in mid-life predicts higher risk of incident vascular, unspecified, and all-cause dementia.
- Higher MileAge delta (difference between metabolomic and chronological age) is linked to earlier dementia onset and key metabolites include lipids, lipoproteins, and amino acids.
- Combining high MileAge delta with two APOE ε4 alleles results in a 10.30-fold increased all-cause dementia risk.
- MileAge delta and genetic risk (APOE genotype, polygenic scores) are jointly associated with dementia, representing independent biological pathways.
- The study suggests metabolomic ageing could help identify individuals at risk for targeted prevention strategies.