Histone variant H2A.X represses deposition of active H3K4me3 marks and restricts H2A.W incorporation - PubMed
2 days ago
- #H2A.X
- #epigenetics
- #H3K4me3
- H2A.X represses deposition of active H3K4me3 marks on gene bodies and transposable elements, regulating genes related to root development, photosynthesis, and pigmentation.
- H2A.X restricts H2A.W incorporation, repressing global H3K9me2 deposition and preventing H2A.W relocalization to TEs and some genes.
- H2A.X overexpression leads to stress phenotypes like increased anthocyanin, mimicking DNA-damaged plant transcriptomes.
- FACT complex knockdown lines show similar transcriptomes to H2A.X knockout, linking FACT's developmental functions to H2A.X.