Impact of lymphatic ablation approaches on immunotherapy efficacy in advanced/metastatic esophageal squamous cell carcinoma: A multi-institutional retrospective cohort study - PubMed
5 hours ago
- #immunotherapy
- #esophageal cancer
- #lymphatic ablation
- Study evaluates the impact of lymphatic ablation approaches (lymphadenectomy or nodal irradiation) on immunotherapy efficacy in advanced/metastatic esophageal squamous cell carcinoma.
- Retrospective analysis of 507 patients treated with ICI-based regimens, including post-surgery/radiotherapy recurrence and treatment-naïve advanced disease cases.
- Optimal lymph node yield range identified: 16-22 dissected lymph nodes (DLNs) associated with longer progression-free survival (PFS) in postoperative recurrence group.
- Prior involved-field irradiation correlated with longer PFS than elective nodal irradiation in post-radiotherapy recurrence patients.
- Findings suggest a balance between locoregional disease management and preservation of lymphatic immune architecture is crucial for immunotherapy efficacy.