Met@MPDA rejuvenates BMSC energy metabolism to promote bone regeneration in semaglutide-treated obese periodontitis - PubMed
4 hours ago
- #energy-metabolism
- #obesity-periodontitis
- #bone-regeneration
- Obesity worsens alveolar bone loss in periodontitis, and semaglutide reduces inflammation but does not promote bone regeneration.
- In obese mice, inflamed alveolar bone shows increased fatty-acid uptake but suppressed AMPK signaling and reduced fatty-acid oxidation (FAO).
- FAO is significantly reduced in bone marrow-derived mesenchymal stem cells (BMSCs) under inflammation, impairing osteogenic differentiation.
- A metformin-loaded mesoporous polydopamine system (Met@MPDA) restores BMSC energy metabolism and promotes alveolar bone regeneration in periodontitis.
- Met@MPDA's sustained metformin delivery may enhance bone regeneration in semaglutide-treated obese periodontitis cases.