Hirsutine mitigates high glucose-induced cell injury via autophagy activation and NRF2/GPX4-mediated ferroptosis inhibition - PubMed
10 hours ago
- #Ferroptosis
- #Hirsutine
- #Diabetic Nephropathy
- Hirsutine, an alkaloid from Uncaria rhynchophylla, shows antioxidant and cytoprotective effects.
- It protects podocytes from high glucose-induced injury by improving cell viability, reducing ROS, and decreasing apoptosis.
- Hirsutine activates autophagy and inhibits ferroptosis via the NRF2/GPX4 pathway, offering potential for diabetic nephropathy therapy.
- The study is limited to in vitro models and requires further validation of autophagy flux and NRF2 dependency.