Curcumin alleviates depression-aggravated psoriasis by targeting MMP9-regulated apoptotic pathways - PubMed
6 hours ago
- #Curcumin
- #Depression
- #Psoriasis
- Depression and psoriasis are highly comorbid, and a causal link was established through cross-sectional data and Mendelian randomization.
- A combined mouse model showed that chronic stress (CUMS) worsens imiquimod-induced psoriasis-like skin lesions.
- Multi-omics analyses identified apoptosis as a key shared pathway, with MMP9 as a central causal gene in both conditions.
- MMP9 was upregulated in skin and brain tissues in the mouse model, linking the two diseases mechanistically.
- Molecular docking predicted strong binding of curcumin to MMP9, and in vivo studies showed curcumin downregulates MMP9, alleviating both depression-aggravated psoriasis and pathological symptoms.
- The findings suggest MMP9-mediated apoptosis as a pathological link and propose curcumin as a dual-treatment strategy for this comorbidity.