ESCRT-Mediated Machinery Directly Drives Cardiac T-Tubule Formation - PubMed
7 hours ago
- #Cardiomyopathy
- #ESCRT
- #T-tubules
- ESCRT proteins, including Chmp4b and Tsg101, play a crucial role in the formation and maintenance of cardiac T-tubules.
- Chmp4b localizes to the dyad during postnatal development and its deletion leads to a complete loss of T-tubules, affecting cardiac structure and function.
- Chmp4b polymerizes and binds to PtdIns(4,5)P2 and other negatively charged membrane lipids, driving plasma membrane invagination.
- Tsg101 is essential for T-tubule formation but becomes dispensable for maintenance in mature cardiomyocytes.
- Chmp4b expression is significantly reduced in dilated cardiomyopathy patients and heart failure models, linking ESCRT machinery to disease conditions.