Activation dynamics of a water-soluble human mu-opioid receptor - PubMed
5 hours ago
- #mu-opioid receptor
- #GPCR activation
- #structural dynamics
- Engineered a water-soluble, thermostable mu-opioid receptor (wsMOR) variant for structural studies.
- wsMOR retains native-like ligand-binding and activation dynamics, useful for drug screening.
- Combined computational and experimental methods revealed wsMOR's conformational flexibility and stabilization upon agonist binding.
- Highlighted the role of transmembrane helix 6 (TM6) in GPCR activation dynamics.
- Findings support the development of safer and more effective opioid ligands.