Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis - PubMed
3 days ago
- #Migraine
- #Mendelian Randomization
- #Cognitive Impairment
- Migraines are causally associated with cognitive impairment according to Mendelian randomization analysis.
- Three strategies were used: polygenic risk score (PRS) method, one-sample MR, and two-sample MR.
- PRS constructed by 18 SNPs showed a causal link (β = -2.31, 95% CI: -4.56 to -0.06).
- One-sample MR confirmed the association (IVW estimator β = 2.90; 95% CI: 0.90-4.89).
- Two-sample MR validated the causal relationship (IVW estimator β = 2.43; 95% CI: 1.08-3.78).
- Migraine is identified as a polygenic disorder linked to cognitive impairment.