CytoSignal detects locations and dynamics of ligand-receptor signaling at cellular resolution from spatial transcriptomic data - PubMed
5 hours ago
- #cell-cell communication
- #spatial transcriptomics
- #ligand-receptor signaling
- CytoSignal is a tool that infers ligand-receptor signaling interactions at cellular resolution from spatial transcriptomic data.
- It identifies spatial gradients in signaling strength, distinguishes contact-dependent and diffusible interactions, detects signaling-associated genes, and enables differential signaling analysis across multiple samples.
- CytoSignal can predict temporal dynamics of signaling at each spatial location and has been experimentally validated using proximity ligation assays.
- The tool addresses the need for robust, scalable detection of cell-cell communication dynamics in spatial transcriptomics.