Mechanism of CircBbs9 in Lung Epithelial Cell Ferroptosis in Lipopolysaccharide-Induced Acute Lung Injury - PubMed
6 hours ago
- #CircBbs9
- #acute lung injury
- #ferroptosis
- CircBbs9 (hsa_circ_0079812) plays a role in LPS-induced acute lung injury (ALI) by promoting ferroptosis in lung epithelial cells.
- CircBbs9 knockdown reduces pulmonary damage, ferroptosis, and ACSL4 expression while increasing cell viability.
- CircBbs9 binds to HuR, inhibiting Cblb expression, which decreases Cblb-mediated ubiquitination and degradation of ACSL4.
- CircBbs9 competitively binds to miR-671-5p, leading to upregulation of ACSL4 expression.
- Cblb knockdown or miR-671-5p inhibition reverses the effects of CircBbs9 knockdown on ferroptosis.
- Simultaneous overexpression of HuR and miR-671-5p has stronger inhibitory effects on ferroptosis than individual overexpression.
- CircBbs9 promotes ferroptosis via the HuR/Cblb/ACSL4 and miR-671-5p/ACSL4 pathways in LPS-induced ALI.