MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity - PubMed
5 hours ago
- #Lung Adenocarcinoma
- #Tumor Suppression
- #Mitophagy
- MAP2K6/MKK3 acts as a tumor suppressor in lung adenocarcinoma by activating mitophagy to suppress tumor growth.
- MKK6/MKK3 uniquely localizes to mitochondrial and autophagosome interaction sites among MAPK kinases, with its tumor-suppressive function relying on kinase activity independent of p38.
- MKK6 directly phosphorylates BCL2L13 at serine 426, enhancing its interaction with LC3B to promote mitophagy, inhibit oxidative phosphorylation (OXPHOS), and prevent tumorigenicity.
- The MKK6-BCL2L13 phosphorylation mechanism at interorganellar sites regulates mitochondrial quality control, offering a potential therapeutic strategy for lung adenocarcinoma treatment.