Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming - PubMed
4 days ago
- #NAD+ metabolism
- #Ovarian function
- #Circadian rhythm
- Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming.
- Long-photoperiod (LP) exposure in rats mimics increased light exposure in humans, reducing ovarian follicles and oocytes.
- LP exposure causes granulosa cell oxidative stress and mitochondrial dysfunction by inhibiting SIRT3 activity and SOD2 deacetylation.
- Metabolomic analysis shows LP exposure lowers NAD+ levels, affecting SIRT3 deacetylase activity.
- NAMPT, a key enzyme in NAD+ synthesis, shows circadian expression in ovaries, disrupted by LP exposure via BMAL1.
- Nicotinamide mononucleotide (NMN) treatment improves mitochondrial function and increases antral follicles and oocytes in LP-exposed rats.
- Targeting NAD+ pathways may offer therapeutic strategies for ovarian diseases caused by circadian disruption.