Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation - PubMed
2 days ago
- #therapeutic targets
- #fibrosis
- #valvular disease
- Functional valve regurgitation (FVR) progression involves active contributions from valvular leaflets, not just external anatomic changes.
- Fibrotic leaflet remodeling scores independently predict the severity of functional mitral regurgitation (FMR) and functional tricuspid regurgitation (FTR).
- FMR and FTR exhibit divergent fibrotic mechanisms: suppressed retinoic acid metabolism in FMR and impaired IFN signaling in FTR.
- Targeted therapies like PDK4 upregulation or IFN signaling activation show potential in reducing FTR severity.
- Leaflet-specific fibrotic remodeling plays a significant role in FVR, with distinct pathways in FMR and FTR.