Neonatal intensive care unit exposures reprogram microbiome-metabolome trajectories and modulate host calprotectin in preterm infants: a longitudinal multi-omics study - PubMed
3 days ago
- #neonatal intensive care
- #preterm infants
- #microbiome
- The study is a longitudinal multi-omics analysis of 186 preterm infants, examining how NICU exposures affect gut microbiota, metabolism, and immune responses.
- Antibiotic exposure suppressed anaerobic bacteria and reduced microbial diversity in a dose-dependent way, with breastmilk feeding helping to lessen these effects.
- The stool metabolome was linked to microbial colonization, and antibiotics disrupted polyamine metabolism associated with anaerobe levels.
- Host calprotectin levels showed a biphasic pattern, correlating with microbial diversity and polyamine metabolites.
- Mediation analysis found that antibiotic-related reductions in calprotectin were driven by anaerobe suppression and polyamine depletion.
- NICU interventions, especially antibiotics, reprogram the preterm gut ecosystem and immune response, with anaerobes and polyamines as key mediators in immune maturation.