Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy - PubMed
5 hours ago
- #Cytotoxic T Cells
- #Neuroinflammation
- #Multiple System Atrophy
- Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy (MSA).
- Peripheral T cells from MSA patients show clonal expansion and cytotoxic features targeting α-synuclein in an HLA-dependent manner.
- CD8+ T cells with cytotoxic and proinflammatory markers are increased in postmortem MSA brain tissues, linking immune activity to neuroinflammation.