Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief - PubMed
7 hours ago
- #piezoelectric gel bandage
- #diabetic wound repair
- #neuropathic pain relief
- A low-intensity focused ultrasound (LIFU)-activated piezoelectric gel bandage is developed for diabetic wound repair and neuropathic pain relief.
- The bandage acts as an artificial 'skin', shielding tissue and serving as a drug reservoir that releases nitric oxide under LIFU to promote macrophage polarization.
- It generates piezoelectric current to desensitize TRPV1 nociceptor for on-demand pain relief and produces reactive oxygen species to eliminate pathogens.
- The regimen promotes CGRP neuropeptides release from sensory neurons to enhance M2-like macrophages-mediated protective cutaneous immunity.
- This strategy is potentially applicable to other non-healing tissue regeneration scenarios.