Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk - PubMed
5 hours ago
- #gut microbiota
- #microglia
- #depression
- Microbiota-driven microglia reprogramming reverses depressive-like behaviors via the Peripheral-to-Central immune crosstalk.
- Gut microbiota intervention, using bedding from non-stressed mice, reversed chronic unpredictable mild stress (CUMS)-induced behavioral changes.
- Single-cell RNA sequencing identified microglial subtypes, with homeostatic microglia 2 (HM2) primarily responding to CUMS and showing a reversible activation trajectory.
- Brain myeloid-derived cells (Mdcs) were key immune cells interacting with microglia, and CUMS disrupted immune cell differentiation via reduced chromatin openness, regulated by Krüppel-like factor Klf2.
- Microbiota remodeling partially reversed epigenetic dysregulation, restoring immune cell migration and activation, offering a novel target for antidepressant strategies.