Efficacy and safety of as-needed albuterol-budesonide versus albuterol in patients with asthma aged 12 to <18 years: design of the randomised, double-blind, parallel-group phase IIIb ACADIA trial - Pu
4 days ago
- #adolescent-health
- #clinical-trial
- #asthma
- The ACADIA trial evaluates as-needed albuterol-budesonide vs. albuterol in adolescents (12-<18 years) with asthma.
- Primary endpoint: annualized rate of severe asthma exacerbations.
- Secondary endpoints include time to first severe exacerbation and systemic corticosteroid exposure.
- Trial design: randomized, double-blind, parallel-group, phase IIIb, involving 440 participants.
- Ethical approval obtained; results to be presented at congresses and published in journals.
- Bayesian dynamic borrowing used to minimize adolescent exposure to study medications.