Engineered Akkermansia muciniphila extracellular vesicles for targeted delivery of miR-21-5p alleviate postmenopausal osteoporosis via PI3K-AKT pathway - PubMed
3 hours ago
- #osteoporosis
- #extracellular vesicles
- #gut-bone axis
- Engineered extracellular vesicles from Akkermansia muciniphila, modified with a bone-targeting peptide, deliver miR-21-5p.
- This delivery system alleviates postmenopausal osteoporosis in mice by activating the PI3K-AKT pathway to promote bone formation and inhibit bone resorption.
- The approach represents a targeted, safe therapeutic strategy leveraging the gut-bone axis and probiotic-derived vesicles for metabolic bone disorders.