IFN-gene signatures in B cells following influenza A and B virus infection and influenza vaccination - PubMed
2 days ago
- #B-cell immunity
- #Interferon signatures
- #Influenza vaccination
- Study examines IFN-gene signatures in B cells post-influenza A/B virus infection and vaccination.
- Increased interferon-stimulated gene signatures (IF44L, IFITM1, XAF1) observed in B-cells from IBV patients, not in IAV patients or vaccinees.
- Phenotypic differentiation and isotype class-switching of HA-specific B-cells noted after vaccination.
- IBVs show higher infectivity in human PBMCs, including B-cells, and reduced B-cell proliferation compared to IAVs.
- Findings aim to inform vaccine design and therapeutic strategies for robust HA-specific B-cell responses.