Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis - PubMed
2 days ago
- #Surgical Site Infections
- #Antibiotic Prophylaxis
- #Colorectal Surgery
- The study compares antibiotic prophylaxis strategies in elective colorectal surgery to reduce surgical site infections (SSIs).
- A network meta-analysis of 105 randomized clinical trials involving 18,273 patients was conducted.
- Broad-spectrum penicillins, third-generation cephalosporins, and combinations like metronidazole with second-generation cephalosporins significantly reduced SSI risk.
- Broad-spectrum penicillins and fluoroquinolone-penicillin combinations also showed significant reductions in 30-day mortality.
- No significant differences were found in hospital length of stay or adverse events between antibiotic classes.
- The certainty of evidence varied from very low to moderate across different outcomes.