DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice - PubMed
7 hours ago
- #regulatory T cells
- #autoimmune diseases
- #nanovesicles
- DC-CD4 bispecific tolerogenic nanovesicles (NV) co-loaded with antigenic peptide and rapamycin induce antigen-specific regulatory T (Treg) cells.
- These NVs promote close spatial proximity between dendritic cells (DCs) and CD4+ T cells via CTLA4-CD80/86 and anti-CD4-CD4 interactions.
- In a collagen-induced arthritis (CIA) mouse model, the NVs show enhanced lymph node tropism and increase antigen-specific Treg cells in lymph nodes and spleen.
- The NVs demonstrate robust efficacy in both therapeutic and prophylactic settings against CIA.
- Adoptive transfer experiments confirm the critical role of NV-induced antigen-specific Treg cells in mediating anti-inflammatory effects.
- The study supports DC-CD4 bispecific tolerogenic NVs as a platform for precise immune tolerance in autoimmune diseases (AIDs).