Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease - PubMed
3 days ago
- #Alzheimer's disease
- #Cognitive restoration
- #mGluR2/3 antagonist
- LY341495, an mGluR2/3 antagonist, treats cognitive deficits in male APP/PS1 Alzheimer's mice.
- Treatment reduces mGluR2/3 upregulation in dentate gyrus, improving synaptic activity, neurogenesis, and calbindin.
- Cognitive performance improves with reduced amyloid-β plaque burden after LY341495 administration.
- Inhibition of mGluR2/3 restores calcium-buffering and neurogenesis, highlighting its therapeutic potential for Alzheimer's.