Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease - PubMed
3 hours ago
- #immunometabolism
- #cell death
- #fasting
- Mitoxyperilysis is a newly discovered mode of cell death.
- It is driven by mitochondrial proximity-dependent rupture of the plasma cell membrane.
- Triggered by immune agonists combined with fasting or nutrient starvation.
- Has potential therapeutic implications in sepsis and cancer.
- Involves key elements like NINJ1, ROS, actin cytoskeleton, cytokines, inflammation, and mTOR.