CPEB1 orchestrates cell cycle-dependent translation of maternal factors to coordinate nuclear-cytoplasmic maturation in porcine oocytes - PubMed
3 days ago
- #translational regulation
- #oocyte maturation
- #CPEB1
- CPEB1 regulates translation of maternal mRNAs to synchronize nuclear and cytoplasmic maturation in porcine oocytes.
- Comparative analysis shows porcine and human oocytes share more translational similarities than with mice.
- In vitro maturation (IVM) leads to defective translation of key genes like GPLD1 and HNRNPK, reducing oocyte quality.
- CPEB1 activates translation of cell cycle-dependent factors via CPEs in 3'UTRs, coordinating maturation.
- Findings provide insights for improving livestock reproductive efficiency through enhanced IVM protocols.