Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors - PubMed
6 hours ago
- #metabolic engineering
- #glutamine metabolism
- #CAR-macrophage
- Metabolic engineering of SLC38A2 in CAR-macrophages reprograms glutamine utilization to enhance antitumor function in solid tumors.
- Tumor-associated macrophages in breast cancer show impaired glutamine metabolism and reduced SLC38A2 transporter expression.
- SLC38A2 overexpression in anti-HER2 CAR-Ms boosts glutamine uptake and phagocytosis of HER2+ cancer cells, improving antitumor activity.
- This strategy offers a promising approach to enhance CAR-M-mediated suppression of solid tumors by restoring glutamine metabolic fitness.