The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome - PubMed
5 hours ago
- #Alzheimer's disease
- #biomarkers
- #Down syndrome
- Study evaluates plasma proteomic profiles for predicting amyloid positivity in adults with Down syndrome (DS).
- Analyzed data from 290 adults with DS using SIMOA to measure biomarkers like Aβ42, Aβ40, NfL, GFAP, and tau.
- Age, GFAP, and NfL were the top contributors to model performance in predicting amyloid positivity.
- Proteomic profile achieved an AUC of 96% in models both with and without APOE ε4, indicating high effectiveness.
- Findings suggest plasma biomarkers can identify amyloid positivity independently of APOE ε4 status, aiding clinical triage and trial selection.