Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness - PubMed
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- #non-small cell lung cancer
- #immune evasion
- #eIF4F
- Pro-SFTPB expression is lower in tumor tissues compared to adjacent tissues in 34%-43% of resectable NSCLC patients.
- Low pro-SFTPB expression correlates with poor response to neoadjuvant chemoimmunotherapy and higher recurrence rates.
- Pro-SFTPB inhibits cancer stemness and immune evasion in NSCLC and enhances PD-1 inhibitor efficacy.
- Targeting eIF4F improves sensitivity to PD-1 inhibitors in NSCLC with low pro-SFTPB expression.
- Pro-SFTPB inhibits eIF4F complex formation by binding to eIF4A1, suppressing translation of c-myc and PD-L1.
- Downregulation of SFTPB mRNA disrupts pro-SFTPB's negative regulation on eIF4F, promoting tumor stemness and immune escape.